The Coompana area is characterised by several thick basin cover sequences dominantly composed of limestone, and forms the topographically flat Nullarbor Plain. Consequently, this region was previously considered too challenging for mineral exploration. However, a strong magnetic anomaly exists at Coompana and preliminary geochemical work by other researchers suggested that a surface geochemical signature was present and may be linked to this deep subsurface feature/anomaly. A collaboration between the Geological Survey of South Australia (GSSA) and CSIRO aimed to understand the regional surface geochemistry, potential geochemical dispersion through the cover and also to establish a workflow for large scale, rapid geochemical sampling that is transferable to other regions of interest for GSSA. The work reported herein builds on the findings of geophysical studies (Foss et al., 2017) and of the Coompana exploratory drilling program (Dutch et al., 2018a), and specifically determines the multi-element geochemistry of the near surface on a regional basis, with the addition of some limited determinations of down regolith profile geochemistry which were integrated with laboratory assay results for the cored drillhole basement chemistry obtained as part of the Coompana exploratory drilling program. The area covered for regional surface sampling covers an estimated 50 km x 80 km grid, with samples taken at 4 km spacing. The sampled area overlaps with the Coompana magnetic anomaly and extends further west and north. GSSA completed a much more detailed regolith map of this area, too, which provided regolith and landform control (Krapf & Irvine, 2018). The project successfully characterised the background geochemistry of the surface, providing a valuable baseline data set for future exploration in related areas. It also was highly successful in developing a workflow for the rapid regional characterisation of large tracts of land. The combination of best practice regional geochemistry with surface samples, landscape models and existing geophysical and down-hole drilling studies provides new geoscience products and a better understanding of the Coompana region.