The Square Kilometre Array (SKA) is a proposed radiotelescope receiver network that, when constructed, will have an effective collection area of one square kilometre, making it up to 100 times more sensitive than any present-day instrument on Earth. The SKA will probably consist of a distributed collection of many radio receiver array stations arranged symmetrically or asymmetrically about a central site. This central site needs to be located in a 'radio-quiet zone' for effective collection of radio waves. After the SKA project proponents recently carried out a GIS assessment of South Australia, five areas were determined to meet the radio-quiet requirements and the other criteria deemed necessary for a suitable SKA site. Of these five areas Murnpeowie Station, a cattle station 730 km north of Adelaide, 130 km NE of Lyndhurst and ~100 km east of Marree, has been chosen as South Australia's preferred site to host a SKA. If Australia and South Australia are successful in securing the SKA, an area of the State would need to be excluded from all activities including mineral and petroleum exploration and mining for the approximately 100 years duration of the project. This report analyses the mineral and petroleum prospectivity of a radial 50 km zone centred on the proposed Murnpeowie Station SKA site, with a view to excluding an inner radial 20 km zone from mineral and petroleum exploration and mining. The previous exploration targets of mineral exploration companies are an indication of the potential mineral deposits of a region. This report qualitatively analyses the SKA 50 km zone for these exploration targets, and an estimate of the potential within the SKA 20 km zone has been determined. Review and analysis of geoscientific data for this region indicates that there is limited potential for the SKA 20 km zone to contain a viable mineral or petroleum resource. Accordingly, it is recommended that this zone be reserved from ongoing mineral and petroleum exploration and development activities through a South Australian Government Gazettal Notice, pursuant to Section 15 of the Mining Act, 1971, being made by the Director of Mines, to remain in place at least until such time as the final SKA site is chosen by the International SKA Steering Committee.