Burial history analysis of the structurally complex eastern Officer Basin region was performed using data from petroleum, trona exploration and stratigraphic wells, seismic upholes, coal drillholes and selected seismic sections, to construct isopachs of the major depositional sequences and to guide interpretation of the amount of section lost during uplift phases. Formation tops, underlying and overlying units and the total present thickness of each sedimentary package were recorded for all significant wells. For purposes of discussion four key wells were selected to represent the principal contrasting tectonic settings and stratigraphic elements being investigated. The conclusions reached are as follows: 1. Early Neoproterozoic potential source rocks are in the oil window on the Murnaroo Platform; 2. early maturity of Neoproterozoic rocks was reached shortly before the end of the Petermann Ranges Orogeny; 3. potential source rocks in the Early Cambrian were initially mature in the Manya Trough prior to the Delamerian Orogeny anf fully mature for hydrocarbon generation on the Murnaroo Platform prior to the Alice Springs Orogeny; 4. secondary porosity is related to alternating episodes of burial and uplift; 5. consideration of burial history curves can improve stratigraphic correlation in thick clastic sequences devoid of marker beds and microfossils.