The Neoproterozoic to Palaeozoic Officer Basin is located on and adjacent to the northwestern margin of the Gawler Craton. Deposition of the basin began in Adelaidean time, before and during the breakup of the supercontinent Rodinia. The Neoproterozoic sediments occurring on the Murnaroo Platform are predominantly siliciclastics with minor carbonates, whereas Cambrian strata in the Manya Trough contain mainly carbonates. Drillcore study has revealed that the Cambrian Observatory Hill Formation carbonates in Meramangye 1 contain thin (~2 m) weakly anomalous zinc-lead zones, and recent interpretation suggests that most previous exploration drillholes (mainly for trona) put down in the Manya Trough are not on structure. Seismic and aeromagnetic surveys plus basin analysis indicate that the Cambrian carbonates were deposited in sag/rift structures which have potential for sedex and other styles of mineralisation in or near fault zones; the Devono-Carboniferous Alice Springs Orogeny reversed the major faults in this region, so extensive thrusting may have generated significant fluid flows of brines from the north towards carbonate rocks in the south, possibly forming MVT deposits. Two prospective areas for zinc-lead and other mineral exploration on the Murnaroo Platform and in the Manya Trough are proposed.